PML/RARa hybrid gene detection – semi-quantitative analysis

The t(15;17) translocation is characteristic to a fraction of patients presenting with de novo acute myeloid leukemia (AML), leading to the expression of a hybrid PML/RARa RNA.

A semi-quantitative RT-PCR method is applied, from a peripheral blood or bone marrow sample, allowing the detection of at least 10 RNA copies of PML/RARa RNA.

This test may also be applied in combination with: