Deletion 6q23-26 detected by MLPA

Deletion of the long arm of chromosome 6 is frequently observed in acute lymphocytic leukemia (ALL), in chronic lymphocytic leukemia (CLL), in prolymphocytic leukemia and non-Hodgkin lymphomas. The deletion often includes the MYB gene.

The detection is based on a custom MLPA technique, using multiple probes in the region under investigation.

This test may also be applied in combination with:

  • Karyotyping of bone marrow cells combined with molecular detection of multiple chromosomal rearrangements
  • Multicolor karyotype (M-FISH)