Deletions at chromosome 13q14 include the RB1 gene and occur often in multiple myeloma, in 20% of cases of B-chronic lymphocytic leukemia (B-CLL) as well as in non-Hodgkin lymphoma. The detection is based on a custom MLPA technique, using multiple probes in the region under investigation.
This test may also be applied in combination with:
- Karyotyping of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)