Duplication of the MYCN gene at 2p24 occurs in many neoplasias and also in cases of chronic lymphocytic leukemia (CLL).
The detection is based on a custom MLPA technique, using multiple probes in the region under investigation.
This test may also be applied in combination with:
- Karyotype analysis of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)