The t(14;18) translocation leads to the formation of the IGH/BCL2 hybrid gene, and is an indication of non-Hodgkin lymphoma (NHL). It is also the second most common translocation of the IGH gene in chronic lymphocytic leukemia (CLL).
This test is useful for patients with hemopoietic disorders for the diagnosis and/or confirmation of chronic and acute leukemia, for evaluation of remission or relapse or even after bone marrow transplantation for evaluation of recurrence of the disorder. The translocation is detected through FISH, using specific custom-labeled DNA probes, from at least 100 bone marrow cell nuclei.
This test may also be applied in combination with:
- Karyotype analysis of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)