Risk assessment for age related macular degeneration (ARMD4)

This particular type of disorder (ARMD4, ΟΜΙΜ #610698) constitutes the main cause for diminished vision of individuals aged over 65 years. Approximately 25% of all individuals aged between 65-74 years and 40% of individuals aged 75-84 years present with pathological symptoms of the disease. Specific polymorphisms in the CFH (complement factor H) gene and ARMS2 (LOC 387715) gene act independently and increase the risk for this disorder substantially, while other polymorphisms confer a protective role. Their combined detection, in combination with the evaluation of other known risks for the disease, is an important tool for the prevention and management of the disease.

The detection of polymorphisms CFH Y402H, LOC387715 A69S, C2 and BF is offered, for the overall assessment of the risk for the disease.