Deletion 3q27 detected by FISH

Deletion 3q27 of chromosome 3 is often related with rearrangements of the BCL6 gene, located in this particular region and occurs in non-Hodgkin lymphomas (NHL).

The deletion is detected through FISH, using specific custom-labeled DNA probes, from at least 100 bone marrow cell nuclei.

This test may also be applied in combination with:

  • Karyotype analysis of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements

Multicolor karyotype (M-FISH)