Deletion 3q27 of chromosome 3 is often related with rearrangements of the BCL6 gene, located in this particular region and occurs in non-Hodgkin lymphomas (NHL).
The deletion is detected through FISH, using specific custom-labeled DNA probes, from at least 100 bone marrow cell nuclei.
This test may also be applied in combination with:
- Karyotype analysis of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
Multicolor karyotype (M-FISH)