Deletion 10q23 on chromosome 10 occurs typically in chronic lymphocytic leukemia (CLL) and is related to the PTEN tumor suppressor gene. The detection is based on a custom MLPA technique, using multiple probes in the region under investigation.
This test may also be applied in combination with:
- Karyotyping of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)