Antibodies Anti-Jo 1

Although anti-Jo-1 antibodies are often included with ANAs, they are actually antibodies to the cytoplasmic protein, histidyl tRNA synthetase. They are highly associated with polymyositis and dermatomyositis, and are rarely found in other connective tissue diseases. Around 20–40% of polymyositis is positive for Jo-1 antibodies and most will have interstitial lung disease, HLA-DR3 and HLA-DRw52 human leukocyte antigen (HLA) markers; collectively known as Jo-1 syndrome.

  • Sample of blood serum
  • We perform the test every Tuesday & Friday