AML1/ETO hybrid gene detection – semi-quantitative analysis

Acute promyelocytic leukemia (APL) is characterized by the presence of the chromosome translocation product t(8;21), which leads to the expression of a hybrid AML1/ETO RNA.

A semi-quantitative RT-PCR method is applied, from a peripheral blood or bone marrow sample, allowing the detection of at least 10 RNA copies of AML1/ETO RNA.

This test may also be applied in combination with: